| Title |
A common antimicrobial additive increases colonic inflammation and colitis-associated colon tumorigenesis in mice
|
|---|---|
| Published in |
Science Translational Medicine, May 2018
|
| DOI | 10.1126/scitranslmed.aan4116 |
| Pubmed ID | |
| Authors |
Haixia Yang, Weicang Wang, Kymberleigh A Romano, Min Gu, Katherine Z Sanidad, Daeyoung Kim, Jun Yang, Birgitta Schmidt, Dipak Panigrahy, Ruisong Pei, Derek A Martin, E Ilker Ozay, Yuxin Wang, Mingyue Song, Bradley W Bolling, Hang Xiao, Lisa M Minter, Guang-Yu Yang, Zhenhua Liu, Federico E Rey, Guodong Zhang |
| Abstract |
Triclosan (TCS) is a high-volume chemical used as an antimicrobial ingredient in more than 2000 consumer products, such as toothpaste, cosmetics, kitchenware, and toys. We report that brief exposure to TCS, at relatively low doses, causes low-grade colonic inflammation, increases colitis, and exacerbates colitis-associated colon cancer in mice. Exposure to TCS alters gut microbiota in mice, and its proinflammatory effect is attenuated in germ-free mice. In addition, TCS treatment increases activation of Toll-like receptor 4 (TLR4) signaling in vivo and fails to promote colitis in Tlr4-/- mice. Together, our results demonstrate that this widely used antimicrobial ingredient could have adverse effects on colonic inflammation and associated colon tumorigenesis through modulation of the gut microbiota and TLR4 signaling. Together, these results highlight the need to reassess the effects of TCS on human health and potentially update policies regulating the use of this widely used antimicrobial. |
X Demographics
The data shown below were collected from the profiles of 346 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 97 | 28% |
| United Kingdom | 26 | 8% |
| Canada | 15 | 4% |
| India | 8 | 2% |
| France | 7 | 2% |
| Mexico | 4 | 1% |
| Spain | 4 | 1% |
| Australia | 4 | 1% |
| New Zealand | 3 | <1% |
| Other | 24 | 7% |
| Unknown | 154 | 45% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 262 | 76% |
| Scientists | 48 | 14% |
| Practitioners (doctors, other healthcare professionals) | 30 | 9% |
| Science communicators (journalists, bloggers, editors) | 6 | 2% |
Mendeley readers
The data shown below were compiled from readership statistics for 169 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 169 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 15% |
| Researcher | 21 | 12% |
| Student > Bachelor | 16 | 9% |
| Student > Master | 14 | 8% |
| Student > Doctoral Student | 10 | 6% |
| Other | 34 | 20% |
| Unknown | 49 | 29% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 15% |
| Agricultural and Biological Sciences | 23 | 14% |
| Medicine and Dentistry | 18 | 11% |
| Immunology and Microbiology | 16 | 9% |
| Chemistry | 6 | 4% |
| Other | 22 | 13% |
| Unknown | 58 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 920. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2023.
All research outputs
#18,564
of 25,452,734 outputs
Outputs from Science Translational Medicine
#73
of 5,444 outputs
Outputs of similar age
#363
of 344,467 outputs
Outputs of similar age from Science Translational Medicine
#4
of 101 outputs
Altmetric has tracked 25,452,734 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,444 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 86.6. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 344,467 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 101 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.