| Title |
TSLP Elicits IL-33–Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation
|
|---|---|
| Published in |
Science Translational Medicine, January 2013
|
| DOI | 10.1126/scitranslmed.3005374 |
| Pubmed ID | |
| Authors |
Brian S. Kim, Mark C. Siracusa, Steven A. Saenz, Mario Noti, Laurel A. Monticelli, Gregory F. Sonnenberg, Matthew R. Hepworth, Abby S. Van Voorhees, Michael R. Comeau, David Artis |
| Abstract |
Innate lymphoid cells (ILCs) are a recently identified family of heterogeneous immune cells that can be divided into three groups based on their differential developmental requirements and expression of effector cytokines. Among these, group 2 ILCs produce the type 2 cytokines interleukin-5 (IL-5) and IL-13 and promote type 2 inflammation in the lung and intestine. However, whether group 2 ILCs reside in the skin and contribute to skin inflammation has not been characterized. We identify a population of skin-resident group 2 ILCs present in healthy human skin that are enriched in lesional human skin from atopic dermatitis (AD) patients. Group 2 ILCs were also found in normal murine skin and were critical for the development of inflammation in a murine model of AD-like disease. Remarkably, in contrast to group 2 ILC responses in the intestine and lung, which are critically regulated by IL-33 and IL-25, group 2 ILC responses in the skin and skin-draining lymph nodes were independent of these canonical cytokines but were critically dependent on thymic stromal lymphopoietin (TSLP). Collectively, these results demonstrate an essential role for IL-33- and IL-25-independent group 2 ILCs in promoting skin inflammation. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 10% |
| United Kingdom | 1 | 10% |
| Unknown | 8 | 80% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 8 | 80% |
| Scientists | 1 | 10% |
| Practitioners (doctors, other healthcare professionals) | 1 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 401 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Germany | 1 | <1% |
| Canada | 1 | <1% |
| United Kingdom | 1 | <1% |
| Japan | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Unknown | 392 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 77 | 19% |
| Researcher | 71 | 18% |
| Student > Master | 48 | 12% |
| Student > Bachelor | 35 | 9% |
| Student > Doctoral Student | 18 | 4% |
| Other | 69 | 17% |
| Unknown | 83 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 103 | 26% |
| Immunology and Microbiology | 84 | 21% |
| Medicine and Dentistry | 59 | 15% |
| Biochemistry, Genetics and Molecular Biology | 33 | 8% |
| Neuroscience | 5 | 1% |
| Other | 25 | 6% |
| Unknown | 92 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 October 2021.
All research outputs
#2,748,850
of 25,603,577 outputs
Outputs from Science Translational Medicine
#3,072
of 5,459 outputs
Outputs of similar age
#26,931
of 291,776 outputs
Outputs of similar age from Science Translational Medicine
#46
of 105 outputs
Altmetric has tracked 25,603,577 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,459 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 86.7. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
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