Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/23ps6nURHT
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/nMcYeqoB9Y
Awesome work by @JSheltzer which finally clarifies the MOC of OTS964: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/NrGKafDSvZ
A must read from one of the best!
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Imprecision oncology: https://t.co/yRM3H2op5c
"cancer biology & therapeutics"
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @matthewherper: Wait this is crazy. https://t.co/eLfjAzsxmj
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Great walk through of great work! Elegant use of CRISPR to scrutinize the true targets of “targeted” therapies.
what a great paper! that's why my lab is a big fan of the systems-based approach. Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/Zi95qZPJb5
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
This is mind-blowing.
this is amazing work
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
So how many drugs in #psychiatry or #neurology actually work the way pharmacologists think they do, by targeting dopamine or serotonin or acetylcholine? -- can't treat brain cells as easily like yeast, though
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
@macesari @DLVetrano
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Crazy
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
So should we call this phenomenon #OffTargetEfficacy? This highlights the non-equivalence of RNA interference, CRISPR knockout, and pharmacologic inhibition. Understanding of that is vital for #DrugDiscovery.
This is fascinating
Turns out many cancer drugs don't act on their supposed targets. These incorrect mechanism of action relationships stem in part from #offtarget effects in the #RNAi screens that led to the belief they're essential!
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
What a crazy finding. Could these off-target effects be "newly found" because of lack of rigor or more complex biology? --> Off-target toxicity is a common mechanism of action of #cancer #drugs undergoing #clinicaltrials @sciencetm https://t.co/PlzKoijV
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @matthewherper: Wait this is crazy. https://t.co/eLfjAzsxmj
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Via @Chemjobber , wow. And read the thread — lovely explanation of key take-aways with figures, etc.
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @matthewherper: Wait this is crazy. https://t.co/eLfjAzsxmj
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
😯 Drug development is so very broken.
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
thread time!
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @carlzimmer: When the subject of your article goes off an tells the story for himself in a Twitter thread https://t.co/O4Jo4lwXa7
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Según estudio, varios candidatos a medicamentos contra el #cáncer en los ensayos clínicos matan las células tumorales mediante efectos que se producen de forma inesperada, en lugar de interactuar con los objetivos moleculares previstos @CSHL https://t.co/K
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Brb shorting some stocks
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @matthewherper: Wait this is crazy. https://t.co/eLfjAzsxmj
RT @matthewherper: Wait this is crazy. https://t.co/eLfjAzsxmj
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Super fascinating paper. Definitely check this out if you have an interest in cancer drug development.
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
I’ll stop retweeting each individual tweet in the thread if you all promise to read the whole thing.
Wait this is crazy.
@HuhnDaniela have a look at this!
RT @carlzimmer: When the subject of your article goes off an tells the story for himself in a Twitter thread https://t.co/O4Jo4lwXa7
CSHL Fellow Jason Sheltzer and his colleagues are rocking the medical news headlines with their latest results. If you're interested in the finer details and behind-the-scenes insights, check out this thread 👇
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
very important study to improve novel drug translational rates in humans. Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials | Science Translational Medicine https://t.co/J21Os9vC1c
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
Think there might be one or two diabetes drugs that work through "off-target" mechanisms.
Very neat study: mechanisms underlying the effect of several #cancerdrugs may actually be through off-target toxicity: https://t.co/P59Or9Mlee via @ScienceTM #clinicaltrials #CRISPR
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/OwFhctVAba
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
When the subject of your article goes off an tells the story for himself in a Twitter thread
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Beautiful study! Worth a read. So many lessons, including that many drug mechanisms-of-action are wrong. Bravo!
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
Cool work and fantastic tweet summary
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
extremely important study - also gratifying to see it confirms my model organism researcher bias that tons of cell line drug + target work is...erm...not totally absolutely bombproof let's say? super stuff.
Science-geek thread (and really good research)
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
🤯🤯🤯
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…