Thought-provoking read: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/TL2fO75KEd
@ScottGottliebMD We may need to rethink how "well understood" the mechanism of action of drugs are. Ex: https://t.co/wDX1HxFNek
Worthy read! https://t.co/caFmffWIoC
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @raqbio: OTSの開発したMELK阻害剤OTS167及びTOPK阻害剤OTS964(514)が、実際はoff-targetに作用してがん細胞に影響しているのではないか?ということに一部触れている論文 https://t.co/HodC9S9pma
RT @DoctorBou: “97% percent of drug-indication pairs that are tested in clinical trials in oncology never advance to receive U.S. FDA appro…
OTSの開発したMELK阻害剤OTS167及びTOPK阻害剤OTS964(514)が、実際はoff-targetに作用してがん細胞に影響しているのではないか?ということに一部触れている論文 https://t.co/HodC9S9pma
RT @CancerConnector: @EricTopol @kaznatcheev As for missing ‘shake-ups’ I’d add @JSheltzer gorgeous work showing when we use targeted thera…
RT @EricTopol: @ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #c…
RT @Meaningness: This 🧵 seems important for cancer, but also drug discovery in general, and molecular biology in general, and even science…
RT @DoctorBou: “97% percent of drug-indication pairs that are tested in clinical trials in oncology never advance to receive U.S. FDA appro…
RT @DoctorBou: “97% percent of drug-indication pairs that are tested in clinical trials in oncology never advance to receive U.S. FDA appro…
RT @EricTopol: @ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #c…
RT @EricTopol: @ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #c…
RT @EricTopol: @ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #c…
RT @EricTopol: @ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #c…
RT @EricTopol: @ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #c…
RT @EricTopol: @ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #c…
@jyoti_k_jaiswal @Mayank_Verma_ I wonder whether the effect contributes to the following results https://t.co/J5cJWBvKnC
RT @EricTopol: @ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #c…
RT @EricTopol: @ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #c…
RT @EricTopol: @ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #c…
@ellie_kincaid @ivanoransky @Medscape Adding 3 2019 papers that challenged conventional wisdom: 1. Off-target toxicity of #cancer drugs https://t.co/g3jbu7c7jS @ScienceTM by @JSheltzer et al, thanks @CancerConnector 2. Phage resistant to #CRISPR, by @joeBo
@EricTopol @ellie_kincaid @ivanoransky @Medscape What did think of this paper https://t.co/WcA48WuhAi ?
Drugs may not do what we think they do https://t.co/cCqa7x0E0Y
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
1. Wild resynthesis of E. coli genome: https://t.co/NemZEZTR1T 2. CRISPR uncovering real targets of oncologic drugs: https://t.co/BMEBn39XHa 3. Nice, fresh rundown of current gene therapies around the world: https://t.co/Q82N4cssdo
@EricTopol @kaznatcheev As for missing ‘shake-ups’ I’d add @JSheltzer gorgeous work showing when we use targeted therapy we aren’t always (maybe we are rarely) doing what we think were doing. https://t.co/YFTbs5vY00
If you study cancer or pharma or RNAi or CRISPR, you should definitely read this paper from @JSheltzer et al. It has incredibly important ramifications. https://t.co/w1AksHesG5
@EvolSci @TanentzapfLab Reminds me of this barn-burner of a paper. https://t.co/w1AksHw44F
RT @naaaaaaato2018: 簡単に要約すると、 一部の分子標的薬は、標的タンパクに作用していないが、なぜか抗腫瘍効果を示している です 議論を呼ぶ論文だと思うんですが、実際どうなんでしょう? Off-target toxicity is a common mech…
RT @naaaaaaato2018: 簡単に要約すると、 一部の分子標的薬は、標的タンパクに作用していないが、なぜか抗腫瘍効果を示している です 議論を呼ぶ論文だと思うんですが、実際どうなんでしょう? Off-target toxicity is a common mech…
RT @naaaaaaato2018: 簡単に要約すると、 一部の分子標的薬は、標的タンパクに作用していないが、なぜか抗腫瘍効果を示している です 議論を呼ぶ論文だと思うんですが、実際どうなんでしょう? Off-target toxicity is a common mech…
RT @drmattmcfarlane: @HenningWillers @PhilosopherMD1 @theNCI @RRS_RadRes @ASTRO_org @kaelin_lab How can we expect therapies to work if the…
RT @drmattmcfarlane: @HenningWillers @PhilosopherMD1 @theNCI @RRS_RadRes @ASTRO_org @kaelin_lab How can we expect therapies to work if the…
RT @drmattmcfarlane: @HenningWillers @PhilosopherMD1 @theNCI @RRS_RadRes @ASTRO_org @kaelin_lab How can we expect therapies to work if the…
@HenningWillers @PhilosopherMD1 @theNCI @RRS_RadRes @ASTRO_org @kaelin_lab How can we expect therapies to work if the targets don’t matter and the drugs don’t even hit the targets? @JSheltzer https://t.co/pz3cH32yHF
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
RT @JSheltzer: Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specifi…
Thanks to funding from @AmericanCancer, we're looking to hire a postdoc to study anti-cancer drug targeting and drug specificity. I believe that this research will have an important clinical impact, and I'm happy to consider applicants from all scientific
@LauredelaVega I wouldn’t count on the inhibitor either 🙊 - unless it’s exquisitely selective - KO:siRNA:cpd is like comparing 🍎 to 🍏 to 🍊 ? What did you make of this paper?👇🏼 https://t.co/kUBnWPHP9I
RT @Gritsman_lab: Fascinating and important study - turns out we were wrong about many cancer drug targets https://t.co/4yvQLf1ljD
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
@Simple_Trials Please ask everyone about this disruptive study! https://t.co/m7Jgjtltj9
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @Kaochar2: PCF YIs!! We have an exciting WG talk in store for you tomorrow (11/6 11am-12pm ET). Tune in to hear Dr. Jason @JSheltzer @CS…
RT @Kaochar2: PCF YIs!! We have an exciting WG talk in store for you tomorrow (11/6 11am-12pm ET). Tune in to hear Dr. Jason @JSheltzer @CS…
RT @Kaochar2: PCF YIs!! We have an exciting WG talk in store for you tomorrow (11/6 11am-12pm ET). Tune in to hear Dr. Jason @JSheltzer @CS…
PCF YIs!! We have an exciting WG talk in store for you tomorrow (11/6 11am-12pm ET). Tune in to hear Dr. Jason @JSheltzer @CSHL discuss the accidental discovery of CDK11 inh (this paper rightfully got a LOT of attention 👇) @PCF_Science @JRPCFer @AdamSharpM
RT @YukaTakemon: Yikes, this is pretty concerning. Now, what should happen to these drugs undergoing clinical trials? Off-target toxicity…
RT @FISV998: Perché di tutti i farmaci antitumorali individuati pochissimi superano i trial clinici? La loro tossicità non è specifica: uno…
Perché di tutti i farmaci antitumorali individuati pochissimi superano i trial clinici? La loro tossicità non è specifica: uno studio scopre che in realtà molti di essi non agiscono sul gene target presunto, cioè sono off target. Leggi li studio: https://
Yikes, this is pretty concerning. Now, what should happen to these drugs undergoing clinical trials? Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/X5Q3U9YJej #cancer #science #clinicaltrials
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @LoreLafra: @HuhnDaniela have a look at this! https://t.co/6zf0kgZD3b
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Amazing! Great biological question combined with the right technology gives surprising results. Science at it's best. Well done.
a wisdom-packed tweet series
great thread on cancer research
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…