RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interacting with their intended molecular targets, a new study in ScienceTM shows. https://t.co/ftrkEshXdv https://t.co/1LSt3zz8V
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interacting with their intended molecular targets, a new study in @ScienceTM shows. https://t.co/qflSozVmok https://t.co/YTUg5iCNby
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials. https://t.co/myVFz5b0IX
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/AXnoXStgxL
Read this.
RT @OtagoBiochemist: JOURNAL CLUB Fri 20 Sep @ noon Rm 231 Rowan Herridge: ‘Missing the Target’ https://t.co/WiuAHw0Cdn Matthias Fellner:…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/2M8gvSw8cZ
JOURNAL CLUB Fri 20 Sep @ noon Rm 231 Rowan Herridge: ‘Missing the Target’ https://t.co/WiuAHw0Cdn Matthias Fellner: ‘Are you going to be extinct next year?’ https://t.co/K4HDR3ghtR
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/i4evyCTD7G Great paper! We must remain humble when we talk about “targeted therapies”...
抗がん剤の効果には懐疑的なのだが、やはりかと思った。 分子標的薬は抗がん剤をやり尽くしてから提案され、もはや効いてるかさえ分からなかった。 やり方を変えればガンを叩く効果が上がりそう。患者の福音になってほしい。
え⁇⁇
RT @LindsayWu_UNSW: The dirty secret of drug development: plenty of compounds work via mechanisms that have nothing to do with their intend…
At most scientific meetings, there are large number of newly discovered proteins essential for cancer growth. Imbibition of these often has antitumor effects.. Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials | Science Translational Medicine https://t.co/wgrNhHP1Sh
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @ScienceTM: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interacting wi…
Rigorous and thoughtful work from @JSheltzer lab. Tl;dr we can improve success rates of cancer drug clinical trials if we simply do a better job vetting candidates & genetic targets in pre-clinical stages
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @naaaaaaato2018: 簡単に要約すると、 一部の分子標的薬は、標的タンパクに作用していないが、なぜか抗腫瘍効果を示している です 議論を呼ぶ論文だと思うんですが、実際どうなんでしょう? Off-target toxicity is a common mech…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
Check this out @Judy_ATello
@klin248 is this similar to what you're talking about tomorrow? https://t.co/MzVFV1RXZp
<Anti-cancer> Drugs may not do what we think they do https://t.co/vHDsow1UhR
Off-target toxicity of cancer drugs. How a drug in clinical development can still kill cancer cells even after their ;resumed target protein is knocked out. https://t.co/6uo4OAzoMq
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @o_dewever: Breakthrough paper and glad to see that our work on lack of specificity of HDAC6 inhibitors is cited. https://t.co/NjeNZACOI…
RT @o_dewever: Breakthrough paper and glad to see that our work on lack of specificity of HDAC6 inhibitors is cited. https://t.co/NjeNZACOI…
#compchem folks: check table 1 of this paper about the mechanism of action of cancer drugs to be sure you are not working with the wrong target protein.
RT @LynJone87578509: A thorough case study of chemical and functional genomics. I think it's likely that many drugs and clinical candidates…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
この論文を説明してくれてる記事がありました(´・ω・) 『実際に「MELK阻害剤OTS167」は乳がんの治療薬として高い効果を挙げて』ってところは、OTSの株価が実際にヤバいだけに強調しておこ・・・|ω・) https://t.co/JcDRSy10XO
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @naaaaaaato2018: 簡単に要約すると、 一部の分子標的薬は、標的タンパクに作用していないが、なぜか抗腫瘍効果を示している です 議論を呼ぶ論文だと思うんですが、実際どうなんでしょう? Off-target toxicity is a common mech…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @naaaaaaato2018: 簡単に要約すると、 一部の分子標的薬は、標的タンパクに作用していないが、なぜか抗腫瘍効果を示している です 議論を呼ぶ論文だと思うんですが、実際どうなんでしょう? Off-target toxicity is a common mech…
RT @LynJone87578509: A thorough case study of chemical and functional genomics. I think it's likely that many drugs and clinical candidates…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @hilseth_mistrov: This sums up small molecules in Oncology quite well "Off-target toxicity drives efficacy": https://t.co/CGGNVuIkkD Bri…
RT @LynJone87578509: A thorough case study of chemical and functional genomics. I think it's likely that many drugs and clinical candidates…
RT @LynJone87578509: A thorough case study of chemical and functional genomics. I think it's likely that many drugs and clinical candidates…
RT @LynJone87578509: A thorough case study of chemical and functional genomics. I think it's likely that many drugs and clinical candidates…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @NCIgenomics: A CRISPR-Cas9 mutagenesis study suggests many cancer drugs and drug targets may not do what we think they do https://t.co/…
RT @naaaaaaato2018: 簡単に要約すると、 一部の分子標的薬は、標的タンパクに作用していないが、なぜか抗腫瘍効果を示している です 議論を呼ぶ論文だと思うんですが、実際どうなんでしょう? Off-target toxicity is a common mech…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @naaaaaaato2018: 簡単に要約すると、 一部の分子標的薬は、標的タンパクに作用していないが、なぜか抗腫瘍効果を示している です 議論を呼ぶ論文だと思うんですが、実際どうなんでしょう? Off-target toxicity is a common mech…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @cecilejanssens: This is a jealous making mind-blowing project. What a stunning and important work. https://t.co/hBUX6WrHyR
簡単に要約すると、 一部の分子標的薬は、標的タンパクに作用していないが、なぜか抗腫瘍効果を示している です 議論を呼ぶ論文だと思うんですが、実際どうなんでしょう? Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/8mCqdtBkN4
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/z9CjS6ifcD
This is super interesting...
Interesting, but assuming that CRISPR is a perfect tool? No different than initial exp assuming shRNA was "perfect". Proteome change? Tumor environment? Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https:
A thorough case study of chemical and functional genomics. I think it's likely that many drugs and clinical candidates have a molecular mode-of-action that is different to that originally reported. https://t.co/huz6g1CqTP
RT @MartinFierro769: Anticancéreux. Une étude montre que les cibles ( biomarqueurs) visées par les anticancéreux q n' accèdent pas au march…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/KAW2LWkWs9
RT @zakkohane: Cancer drug targets are frequently not what we think they are. Well demonstrated by #CRISPR screens in this @sciencetm repor…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
#juneliaめも 抗がん剤 誤射がおおい https://t.co/lM6ubDHQh3
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @ShaalanBeg: Hey, so why do we keep using the same preclinical models?! @Aiims1742 @cancerassassin1 https://t.co/Y2hLyEaFsh https://t.co…
RT @o_dewever: Breakthrough paper and glad to see that our work on lack of specificity of HDAC6 inhibitors is cited. https://t.co/NjeNZACOI…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Anticancéreux. Une étude montre que les cibles ( biomarqueurs) visées par les anticancéreux q n' accèdent pas au marché ne sont pas en lien avec la toxicité sur la tumeur. Il est probable q ce soit pareil avc cx q y accèdent avc des procédures accélérées
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @dhjutsw1: ICYMI: Some cancer drugs “work” because they don’t work the way we think they work. Who knew? @UTSWIMchief @UTSWInternalMed @…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…