RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
RT @JSheltzer: Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scie…
Exceptionally pleased to announce that my lab has won an @AmericanCancer Research Scholar Grant! We're looking to hire scientists to figure out how anti-cancer drugs really work. Interested? Shoot me an email!
I asked my journal club course which paper they wanted to read, and after a very tight race, it looks like we're diving into this fantastic work by @JSheltzer! https://t.co/iH2j8z5x3I
RT @KP_twitt_llo: Science friends. If you are into cancer research, VERY much recommended for a Journal Club. It shows very nicely things t…
RT @KP_twitt_llo: Science friends. If you are into cancer research, VERY much recommended for a Journal Club. It shows very nicely things t…
@Geekazoid @mike_jd_daniels @DNEP_UoM @FBMH_UoM Yes, its a great tech - but ignoring off-targets can bring in too many confounding factors. Like this paper criticizing RNAi for off-targets - and will fall in the same trap. https://t.co/WHwILDqMzX Some th
RT @KP_twitt_llo: Science friends. If you are into cancer research, VERY much recommended for a Journal Club. It shows very nicely things t…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @KP_twitt_llo: Science friends. If you are into cancer research, VERY much recommended for a Journal Club. It shows very nicely things t…
RT @KP_twitt_llo: Science friends. If you are into cancer research, VERY much recommended for a Journal Club. It shows very nicely things t…
RT @KP_twitt_llo: Science friends. If you are into cancer research, VERY much recommended for a Journal Club. It shows very nicely things t…
Science friends. If you are into cancer research, VERY much recommended for a Journal Club. It shows very nicely things that we should already know such as: - Most drugs work because of an unknown target. - Don´t trust RNAi. Time to go for CRISPR. https:/
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
https://t.co/Ag40DgyKY3 The Importance of hitting your target!!
@JoshFessel @DrRachaelF I'm reminded of this paper we just discussed in journal club about the "off-target" effects of cancer drugs https://t.co/kMAxFSVv0r
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/AiNsJ35JM9
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Not everything is as it seems https://t.co/vVBzxq4avR
@NicoleKuderer @shilpaonc @peters_solange @OncoAlert @IASLC @CharuAggarwalMD We do not actually know how most chemotherapy drugs or even targeted drugs work https://t.co/BUOQOVrwSD as elegantly demonstrated by @JSheltzer even when we consider their effects
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
This is a really great and eye-opening paper. @JSheltzer @CRISPR
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
A very important paper showing how off-target toxicity is a common mechanism of action in cancer drugs. We owe it to our patients to make sure target specificity of drugs is rigorously validated, before pursuing clinical trials...https://t.co/4QtDpQlrSH
RT @mammothbiosci: Researchers from @CSHL, @stonybrooku, @HofstraU, & @nyit recently showed that some #cancer drugs function through off-ta…
RT @JasonWilliamsNY: “We show that—contrary to previous reports obtained predominantly with RNA interference and small-molecule inhibitors—…
Excellent and horrifying read. My choice for journal club and essential reading for everyone in cancer research, really. And guess I have to correct my #ARID1A review because I cited the HDAC6 dependency now proven wrong. Gotta wonder how much of this is s
RT @ATCC_LGC: An intriguing discovery using #CRISPR shows that several #CancerDrugs in clinical trials don't work the way we thought. This…
RT @mammothbiosci: Researchers from @CSHL, @stonybrooku, @HofstraU, & @nyit recently showed that some #cancer drugs function through off-ta…
@Kenan_e_s @curiouswavefn @TrialSpark Additionally, the other big change that will happen is better preclinical validation. This paper is one of the wildest things I’ve read in a while - and just goes to show how much room there is to test drugs before eve
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @ATCC_LGC: An intriguing discovery using #CRISPR shows that several #CancerDrugs in clinical trials don't work the way we thought. This…
RT @ATCC_LGC: An intriguing discovery using #CRISPR shows that several #CancerDrugs in clinical trials don't work the way we thought. This…
An intriguing discovery using #CRISPR shows that several #CancerDrugs in clinical trials don't work the way we thought. This is an exciting opportunity to improve the power of our #Preclinical testing with genetic approaches 🧬
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/K1pcGzNjTl
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
#cancer Des études cliniques en chimiothérapies montrent des effets sans toucher leur cible théorique. Une étude (in extenso) @sciencemagazine détaille l'importance de savoir ce qu'on fait avant de faire mousser une publi.🧐 https://t.co/TxTqrn1Iqn
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @omlazo: Stop everything. This is HUGE. 😱 https://t.co/rgYPlbwgH0
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials (Rated: Objective) https://t.co/Fxw0dLvnf4
https://t.co/WE807nn0qI Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials #sciencenews https://t.co/sJgbaHnQPG
But it's just…I remember this paper about decision theory in drug design https://t.co/lQWdFjtY9q and huge efficiency gains from just increasing the validity of biological correlates And then I recall this: tons of new cancer drugs are just generic toxins
RT @omlazo: Stop everything. This is HUGE. 😱 https://t.co/rgYPlbwgH0
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/Dw19cCrJic
RT @interneurona: Por qué han fallado tantas #drogas contra el #cáncer ? 👇🏻Tremendo hilo sobre trabajo basado en la tecnología #CRISPR pa…
Por qué han fallado tantas #drogas contra el #cáncer ? 👇🏻Tremendo hilo sobre trabajo basado en la tecnología #CRISPR para demostrar si el #target original de la droga era tal...adivinen @JuvenalRiosLeal @Tlabbea @vhnavia @cpvio @preyesneuro @gmrepetto @H
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @omlazo: Stop everything. This is HUGE. 😱 https://t.co/rgYPlbwgH0
Stop everything. This is HUGE. 😱
All those siRNA's and ASO's in trials and in clinics 'cos people worried about #CRISPR off-target 🤦♂️🤦♂️
RT @AGLeprivier: Are we hitting the right targets in our efforts of tackling cancer? And are some of the cancer drugs working by actually i…
RT @jer_06200: Really inspiring study from @JSheltzer giving a hint why some of 97% of drug-indication pairs that are tested in clinical tr…
Are we hitting the right targets in our efforts of tackling cancer? And are some of the cancer drugs working by actually inhibiting their assumed protein targets? See this new study from @JSheltzer lab. https://t.co/66KMBmZzdK
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @jer_06200: Really inspiring study from @JSheltzer giving a hint why some of 97% of drug-indication pairs that are tested in clinical tr…
RT @jer_06200: Really inspiring study from @JSheltzer giving a hint why some of 97% of drug-indication pairs that are tested in clinical tr…
RT @jer_06200: Really inspiring study from @JSheltzer giving a hint why some of 97% of drug-indication pairs that are tested in clinical tr…