RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
Really inspiring study from @JSheltzer giving a hint why some of 97% of drug-indication pairs that are tested in clinical trials in oncology never advance to receive FDA approval. A MUST read to my point of view. https://t.co/znJKOq4RWM
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
This recent paper, in Science, highlights the importance of performing rigorous drug efficacy and specificity assessments https://t.co/vEHKUElpg5. Contact EpiQMAx for assesing the efficacy of inhibitors of histone PTM writers and erasers.
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @sky_jasonli: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/2M8gvSw8cZ
RT @rajivxgulati: WOW https://t.co/c4jRFN4q0e
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
RT @StearnsLab: Nice work from @JSheltzer that blows up common fallacies of cancer drug discovery. RNAi is not specific for the target locu…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Ilustrative source19: https://t.co/WpHkidDvos
Ilustrative source19: https://t.co/NYRqdL1Xcm
RT @SanjatKanjilal: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/hZNAp3mfw…
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
Cell division "live" a loto of tools to my classes
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @DrXaverius: Paper usando CRISPR: Puede que el motivo por el que llevamos lustros con la mitad de las drogas anti-cáncer no funcionando…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
Cancer drugs don't always work the way we expect them to & this may contribute to the high failure rate of #cancer #clinicaltrials
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
Researchers from @CSHL, @stonybrooku, @HofstraU, & @nyit recently showed that some #cancer drugs function through off-target effects. That is, they affect cancer growth by targeting diff proteins than originally thought https://t.co/TJBNtGEugN. #Mammot
Honestly not surprising to those bridging the fundamental biology and synthesis in drug discovery "Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials" https://t.co/rVD0YrIn6m
good reminder to test assumptions. ~97% of cancer drugs fail clinical trials. a couple of guys saw this figure and thought either 1) we're bad at drug development or 2) the genes we *think* are associated w cancer actually arent turns out they arent htt
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @NatRevClinOncol: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials: https://t.co/1qlQWIGR5x
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
RT @ScienceTM: Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – c…
Research using #CRISPR shows the targets of 10 cancer drug candidates are not essential for the survival of cancer cells – contradicting over 180 previous reports based on RNA silencing. @JSheltzer @CSHL https://t.co/jSn35gCDAl https://t.co/1b2I3zqrBs
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/hZNAp3mfw7 Proof that we're clueless about what we do to patients. Doubt this is limited to oncology. After 70yrs, we still don't fully know how
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/KIXvc2jpMY Interesting as well as frightening...
When a cancer drugs kill cancer cells but not with the knowledge you predicted #genius
RT @LindsayWu_UNSW: The dirty secret of drug development: plenty of compounds work via mechanisms that have nothing to do with their intend…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @GidrolXavier: Eventually a recognition of off-target effects with drugs and not only siRNA! https://t.co/xEdrOKlhq0
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @ScienceTM: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interacting wi…
As a medical student currently studying cancer pharmacology, I’ve developed a recent suspicion that most of our “selective inhibitors” are doing 1000 things in vivo that we aren’t aware of (ex. Methotrexate). Can’t wait to forward this to my classmates I’v
RT @LaskerFDN: Drugs may not do what we think they do, according to a new study in @sciencemagazine. @CSHL researchers used #CRISPR approac…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
a gente não sabe de nada. rs
Off-target effects common mechanism of action of #cancer #drugs undergoing clinical trials https://t.co/qvasF56JaO
Eventually a recognition of off-target effects with drugs and not only siRNA!
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
Beautiful work looking into off-target effects of clinical drug candidates in cancer. What I LOVED about this study was that the authors not only prove an off-target effect, but go on to identify the 'true' target. https://t.co/w5NKnm3W1U https://t.co/TcF
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @NCIgenomics: A CRISPR-Cas9 mutagenesis study suggests many cancer drugs and drug targets may not do what we think they do https://t.co/…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
More press for Sheltzer work Some anticancer molecules are off target Experiments in cell lines suggest that the molecules kill cancer cells through targets they weren’t designed to hit https://t.co/0DtvpR8yNh https://t.co/QCsEPPgWNy via @cenmag #drugdisc
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
Drugs may not do what we think they do, according to a new study in @sciencemagazine. @CSHL researchers used #CRISPR approaches to find that several #cancer drugs target different proteins than originally thought. @JSheltzer https://t.co/jHOlY1LGdJ https:/
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
Off-target #toxicity is a common mechanism of action of cancer drugs undergoing clinical trials #Cancer https://t.co/LP7j1OmSPr
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @ChimicoScettico: Una storia interessante https://t.co/rZke6C2LbP
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…
RT @sciencemagazine: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interact…