RT @StearnsLab: Nice work from @JSheltzer that blows up common fallacies of cancer drug discovery. RNAi is not specific for the target locu…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @oncology_bg: Most of what you “know” is just a “belief”. https://t.co/B1HdQkGWf4
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
抗腫瘍治験薬の97%が臨床試験で脱落する、なぜ。 https://t.co/wtZz3NYOMk @JSheltzer
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/wURJjtrtvz
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @oncology_bg: Most of what you “know” is just a “belief”. https://t.co/B1HdQkGWf4
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @rplenge: Fascinating contrast: We need a chemical probe for every human protein (Target 2035): https://t.co/wXUUW26Hvu But the chemic…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @Gritsman_lab: Fascinating and important study - turns out we were wrong about many cancer drug targets https://t.co/4yvQLf1ljD
RT @Meaningness: This 🧵 seems important for cancer, but also drug discovery in general, and molecular biology in general, and even science…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Genetics, biochemistry, and experiments with controls - FTW
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @ProfBootyPhD: Now that I've read the paper, I am pleased to report: it is truly a thicc snacc. https://t.co/HeopwlmXGX
Great thread and paper
RT @ProfBootyPhD: Now that I've read the paper, I am pleased to report: it is truly a thicc snacc. https://t.co/HeopwlmXGX
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/QVfboj7ut9
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @ashleighg: Worth a read. Whole thread. https://t.co/ZOYaLXAcDC
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/R5EQr8jKGe
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/FTzzcLu56g
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
"small molecules can exhibit off-target effects... our data suggest that, rather than simply being the side effect of a drug, these off-target interactions are frequently the mechanism by which small molecules block cancer growth." https://t.co/KkoQJ3Kwva
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/rXWFVFkviF
RT @AmanHusbands: Holy shit https://t.co/FS0Orhs19J
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @PLMcCarthyMD: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/AtUZxYbNb3
RT @SBurtey: Si il manquait une raison pour passer à CRISPR la voici. Papier très important sur les limites des siRNA pour identifier des c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/AtUZxYbNb3
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
This is big
RT @RoccoGogliotti: Food for thought on the importance of using knockout mice and/or CRISPR cell lines to validate mechanism of action duri…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @avirupguha: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/eACCB2qzeY @Car…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Fantastic thread on a fabulous paper
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @WilliamGerber1: There are many researchers who work in / run cancer labs on Twitter. Can you comment - will the findings in this paper…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
"Lin et al. discovered that a drug candidate in clinical development was effective at killing cancer cells even when its target protein was knocked out, suggesting that its proposed mechanism of action was incorrect." https://t.co/9kWDZP3XEI
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Know thy target - optimize for one protein only to find you really targeted another. https://t.co/ibS7ZDsiro
For a powerful example of the scientific power of CRISPR see this recent paper re using the technology to improve drug development https://t.co/z5qCovJwo8
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Terrific!
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Thanks for such a clear explanation of such exciting work!
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @HyvonenGroup: A must read for anyone doing drug discovery. If this is true for drugs in the clinic or in clinical trials, what must it…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @simonbayly: This paper shows that many experimental cancer drugs are false positives. Even though they hit their intended target, this…
beautiful, elegant, important work
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @ProfBootyPhD: Now that I've read the paper, I am pleased to report: it is truly a thicc snacc. https://t.co/HeopwlmXGX
RT @dirnagl: "A keystone of personalized medicine — identify the genes that drive an individual’s cancer — might be on shaky ground...Might…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
🤔 now this is interesting...
Wow...totally not within my expertise but I think this is really strong work! Brilliant!
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
well that was awesome... from 5min reading this thread, I got every relevant detail of an extremely important paper outside of my immediate field. Thanks @JSheltzer and congrats on the brilliant work!
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/aKNJw3xXlD
RT @pwhook: Very cool paper trying to figure out how cancer drugs work. CRISPR competition assays are wonderful. Follow-up experiments are…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @pdhsu: Great study by my DP5 cohort-mate tearing apart oncology lead finding. if a target was found by in vitro RNAi screening, CRISPRk…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…