RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
What an important finding and quite puzzling. I am very much hoping that this will help better preclinical identification of specific drug targets! Great thread to read👇
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @ShaalanBeg: Hey, so why do we keep using the same preclinical models?! @Aiims1742 @cancerassassin1 https://t.co/Y2hLyEaFsh https://t.co…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
Hey, so why do we keep using the same preclinical models?! @Aiims1742 @cancerassassin1 https://t.co/A1ySm5oTay
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @organischchemie: https://t.co/Sskakuxjex あるタンパク質Aが癌細胞で過剰 →このAを標的に薬Xを開発!承認! →タンパク質Aをクリスパーでノックアウト →癌はなぜか増殖し続ける →薬XをAをノックアウトした細胞に投与…
RT @oncology_bg: Most of what you “know” is just a “belief”. https://t.co/B1HdQkGWf4
in Chinese“是药三分毒是也“. Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials | Science Translational Medicine https://t.co/qUkbBxzaZK
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Somehow not surprised : Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials @BUBBL_Oxford https://t.co/jvCvVvQUZi
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials #Cancers #cancertherapy #clinicaltrials
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @AlanaWelm: Beautiful story, and one we all need to learn from. Of course, cancer breaks all the rules, and results are only as good as…
OK. Many ppl will have seen this by now, but I really want to spell it out: impressive work!
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @AlanaWelm: Beautiful story, and one we all need to learn from. Of course, cancer breaks all the rules, and results are only as good as…
Insightful findings as always from @JSheltzer
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @LabMcDonald: Tell me about it. We're trying to come up with some solutions... https://t.co/wEbPnKaSD9
Tell me about it. We're trying to come up with some solutions... https://t.co/wEbPnKaSD9
RT @ScienceTM: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interacting wi…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @ScienceCrisp: 抗腫瘍治験薬の97%が臨床試験で脱落する、なぜ。 https://t.co/wtZz3NYOMk @JSheltzer https://t.co/NxXxiBag61
Poor eyesight
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @wintonARK: Using crispr it becomes clear that a supermajority of cancer drugs developed through 2015 essentially work by accident. In…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @o_dewever: Breakthrough paper and glad to see that our work on lack of specificity of HDAC6 inhibitors is cited. https://t.co/NjeNZACOI…
RT @NCIgenomics: A CRISPR-Cas9 mutagenesis study suggests many cancer drugs and drug targets may not do what we think they do https://t.co/…
Very important paper on CRISPR validation of cancer drug targets. Thank you for the brilliant explanation and congratulations @JSheltzer
Thread alert ⚡⚡
RT @ScienceTM: Multiple #cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interacting wi…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/HcNZOmDaVO
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Breakthrough paper and glad to see that our work on lack of specificity of HDAC6 inhibitors is cited. https://t.co/NjeNZACOIC
RT @NCIgenomics: A CRISPR-Cas9 mutagenesis study suggests many cancer drugs and drug targets may not do what we think they do https://t.co/…
RT @Labome: Cancer drugs don't always work as intended, researchers warn. https://t.co/PBiE6osPIJ https://t.co/IZCPiRv5WQ
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Fantastic work. Definitely worth the read!
Beautiful story, and one we all need to learn from. Of course, cancer breaks all the rules, and results are only as good as the models we use, but this is a great example of how really digging into cancer mechanisms matters. Read the entire thread!
RT @SWHRAmy: Well explained new finding in #precisionmedicine. https://t.co/MlVDkmV1jv
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Beautiful study that everyone should read!
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @avirupguha: Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/eACCB2qzeY @Car…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @TheDMMcC: Important thread from my colleague @JSheltzer ! The bottom line is that you don't really know a drug's mechanism of action u…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
What a great thread - excited to sit down and read the paper this weekend!
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @Anders_S_Hansen: A great thread summarizing the finding that many cancer drugs in clinical trials don’t actually target the gene they a…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/hFnA4cMr8F
RT @finalvent: 分子標的薬のオフターゲットについて。遺伝子編集で突き止める。 Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical tria…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials | Science Translational Medicine https://t.co/blRmgtNU0Z
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @NCIgenomics: A CRISPR-Cas9 mutagenesis study suggests many cancer drugs and drug targets may not do what we think they do https://t.co/…
RT @wintonARK: Using crispr it becomes clear that a supermajority of cancer drugs developed through 2015 essentially work by accident. In…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…
RT @JSheltzer: Our paper on off-target toxicity of anti-cancer drugs generated a lot of really great discussion! I wanted to answer some of…