Off-target toxicity might play an important role in efficacy of cancer drugs https://t.co/J8Z9FtKv7q #NBThighlight
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @Luke__Ward: This is wild https://t.co/g2CrQuYV6A
RT @HartungIngo: This is a must-read for the drug discovery community & a striking reminder that the days of shRNA based target discovery w…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Using crispr it becomes clear that a supermajority of cancer drugs developed through 2015 essentially work by accident. In biology, almost always and even still it seems, we know less than we think we do.
RT @ICR_London: Read the @ScienceTM paper by @JSheltzer (@CSHL) and colleagues here: https://t.co/ATuBbS3q17
Great study by @JSheltzer unfortunately #sirnaofftargets are a real problem many fail to pay attention to.
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @simonbayly: This paper shows that many experimental cancer drugs are false positives. Even though they hit their intended target, this…
A CRISPR-Cas9 mutagenesis study suggests many cancer drugs and drug targets may not do what we think they do https://t.co/uZCYaT0diL
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @organischchemie: https://t.co/Sskakuxjex あるタンパク質Aが癌細胞で過剰 →このAを標的に薬Xを開発!承認! →タンパク質Aをクリスパーでノックアウト →癌はなぜか増殖し続ける →薬XをAをノックアウトした細胞に投与…
RT @btnaughton: What does it mean if twitter threads communicate results more efficiently than a publication can? Do we need another kind o…
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Very important paper. It is important to note though, that protein inhibition and KO/KD may have very different effects. So, even if the gene is not essential, inhibition of the protein may be toxic, if this inhibited protein is stuck there, blocking the
RT @organischchemie: https://t.co/Sskakuxjex あるタンパク質Aが癌細胞で過剰 →このAを標的に薬Xを開発!承認! →タンパク質Aをクリスパーでノックアウト →癌はなぜか増殖し続ける →薬XをAをノックアウトした細胞に投与…
RT @btnaughton: What does it mean if twitter threads communicate results more efficiently than a publication can? Do we need another kind o…
RT @organischchemie: https://t.co/Sskakuxjex あるタンパク質Aが癌細胞で過剰 →このAを標的に薬Xを開発!承認! →タンパク質Aをクリスパーでノックアウト →癌はなぜか増殖し続ける →薬XをAをノックアウトした細胞に投与…
RT @organischchemie: https://t.co/Sskakuxjex あるタンパク質Aが癌細胞で過剰 →このAを標的に薬Xを開発!承認! →タンパク質Aをクリスパーでノックアウト →癌はなぜか増殖し続ける →薬XをAをノックアウトした細胞に投与…
RT @organischchemie: https://t.co/Sskakuxjex あるタンパク質Aが癌細胞で過剰 →このAを標的に薬Xを開発!承認! →タンパク質Aをクリスパーでノックアウト →癌はなぜか増殖し続ける →薬XをAをノックアウトした細胞に投与…
https://t.co/Sskakuxjex あるタンパク質Aが癌細胞で過剰 →このAを標的に薬Xを開発!承認! →タンパク質Aをクリスパーでノックアウト →癌はなぜか増殖し続ける →薬XをAをノックアウトした細胞に投与 →増殖抑制 →!? オフターゲット効果で薬効が出てる?とのことです こわい…
"...the efficacy of each drug that we tested was unaffected by the loss of its putative target, indicating that these compounds kill cells via off-target effects.". We might not know as much about promising drug targets as we think we do! https://t.co/Bv
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
A ground-breaking study that hits the core of #cancer biology and molecular genetics!!! We ought to re-invent the wheel on cancer biology before we even consider clinical trials! @sciencemagazine
RT @hilseth_mistrov: This sums up small molecules in Oncology quite well "Off-target toxicity drives efficacy": https://t.co/CGGNVuIkkD Bri…
Great article on the challenges of developing targeting therapies https://t.co/qub9ttQRme
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @splon: Succinct thread describing important new study on how wrong we are about many anti-cancer drug targets. https://t.co/FJqhCiM1Fb
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @avgupta_me: Crazy. It's amazing ML has made *any* progress in virtual screening, when drug protein interactions like those disproven he…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @hilseth_mistrov: This sums up small molecules in Oncology quite well "Off-target toxicity drives efficacy": https://t.co/CGGNVuIkkD Bri…
RT @hilseth_mistrov: This sums up small molecules in Oncology quite well "Off-target toxicity drives efficacy": https://t.co/CGGNVuIkkD Bri…
RT @E2DGr1: Drugs may not do what we think they do: Too many mischaracterized drugs! Lin et al., using CRISPR screening, discovered that a…
Awesome use of gene editing
This sums up small molecules in Oncology quite well "Off-target toxicity drives efficacy": https://t.co/CGGNVuIkkD Brilliant read!
今まで抗がん剤を使っても癌が治らなかったのは、そもそも見当違いの対象を攻撃していたからだという論文が #Science にて発表されました。がん細胞のたんぱく質を標的とした『分子標的型治療薬』の効果は、対象としていたたんぱく質とは無関係に増殖を抑制するようです。 https://t.co/qOTC53gg3P
RT @HartungIngo: This is a must-read for the drug discovery community & a striking reminder that the days of shRNA based target discovery w…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @LeonidasPlatan1: What we always suspected for many cancer drugs now proves to be true. Other mechanisms and not the defined target a…
Succinct thread describing important new study on how wrong we are about many anti-cancer drug targets.
very elegant competition assays and important findings regarding on/off-target activity of cancer drugs. lin, giuliano et al., @ScienceTM https://t.co/TYxZ2SHW2u
Astonishing results on off-target effects of anti-cancer molecules. It highlights the importance of negagive controls in MOA elucidation (or: if your drug kills cells that do not express your target protein, maybe you want to rethink you proposed mechanism
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @btnaughton: What does it mean if twitter threads communicate results more efficiently than a publication can? Do we need another kind o…
Many drugs in clinical trials have mechanism of action unrelated to the proposed target! A call for new approaches to target deconvolution. https://t.co/vlfRRpmyIp
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Off-target toxicity is a common mechanism of action of cancer drugs undergoing clinical trials https://t.co/Czs2q8iOyx
RT @btnaughton: What does it mean if twitter threads communicate results more efficiently than a publication can? Do we need another kind o…
Any small-molecule drug is specific until proven otherwise. @ScienceTM #Cancer #CellSignaling https://t.co/l2nzHiIDAo
You'd better double check if you really target the correct protein in your drug design projects ... https://t.co/uc7XwkFeWG
Not easy, but it is important to understand mode of action, validating drug target engagement correctly. https://t.co/4XgqPtHvzb
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
Beautiful paper about targeted therapies - https://t.co/0I9Y540cej. Turns out that quite often one can delete the target for the "targeted" drug and this drug would still work fine.
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @GregVladimer: (1/2) This is pretty cool. It confirms what was expected by many groups, off-targets are inherent, and likely why some pr…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
Found this on twitter yesterday. Found it fascinating. #CRISPR as a key tool for #drugdevelopment and highlighting just how important it is to understand the mechanism of action of new drugs... preferably before they enter #clinicaltrials. #basicscience ht
RT @kmerz1: Know thy target - optimize for one protein only to find you really targeted another. https://t.co/ibS7ZDsiro
RT @PWMJohnson: Very important confirmation in the lab of what we see in the clinic: poor correlation between putative mechanism and result…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @EricTopol: 97% of #cancer drugs tested fail. Why? When @carlzimmer is on-target about off-target cancer drugs, as determined by #CRISPR…
Fancy some Friday breakfast #cancerresearch? Read this spectacular thread on the importance of nuts-and-bolts fundamental biology, and really - REALLY - understanding what’s going on with your experiments 🧪 🔬 👩🔬
Great work! Congrats. It rrally means we think we know a lot of things that we don't know. Do wrong so many times!
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @ashleighg: Worth a read. Whole thread. https://t.co/ZOYaLXAcDC
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…
RT @Gritsman_lab: Fascinating and important study - turns out we were wrong about many cancer drug targets https://t.co/4yvQLf1ljD
RT @JSheltzer: Our new paper is out today. We used CRISPR to uncover some really striking findings with several drugs and drug targets in c…